Everything You Need to Know About TB4-Frag Oral

This entry was posted in Vitamins & Supplements and tagged on by .

TB4-Frag Oral

Thymosin Beta 4, more commonly known as TB4, is a peptide that originates in the thymus within the body. While most people have heard very little about this naturally occurring hormone, it is more involved in our bodies’ day-to-day operations than you might think.

TB4 is responsible for helping the body produce not only healthy blood cells that transport nutrients throughout your body but also blood cells that comprise the immune system and keep inflammation from injury at a minimum. In addition, this crucial peptide can help speed up the recovery process of many of the organs and tissues in your body. TB4 is important whether you have tissues that are damaged from injury, exercise, surgery, or any other cause.

Natural TB4 produced in the body is composed of more than 40 amino acids, which can reduce its bioavailability (the body’s ability to utilize all TB4 to its maximum benefit). Fortunately, researchers have created synthetic TB4 products such as TB4 Frag Max and TB4 Frag Oral that reduce the number of amino acids involved so the body can benefit from TB4.

Here, we examine TB4 in-depth, including its benefits and why it may be the right supplement for you to include in your peptide therapy regimen.

What Is TB4 Frag Oral?

Peptides, including TB4, are building blocks of proteins that are composed of chains of amino acids. Peptides are crucial for protein formation but can also act as hormones and serve other bodily functions. Although the body should naturally produce TB4, there are some limitations to its bioavailability due to the number of amino acids that form the peptide. In addition, while thymosin beta 4’s production in the thymus begins around age 15, it begins to taper off around the ages of 35-45. For those familiar with the body’s aging process, this is often when more chronic diseases and debilitating conditions set in. As a result, it is critical for many people to supplement with a more bioavailable version of TB4.

TB4 Frag Oral is a synthetically created peptide supplement that is designed to help the body benefit from the healing and strengthening properties of the TB4 peptide by reducing its size.

Frag refers to the 4-amino-acid “fragment” of the TB4 peptide. In synthetic TB4 frag products, the amino acid count is reduced from over 40 to just four, making it much more readily available to the body. The TB4 Frag Oral effects are mirrored and extended in another product called TB4 Frag Max. TB4 Frag Max offers up to 10 times the benefits of TB4 Frag Oral, as it consists of nearly as many amino acids as the naturally occurring peptide but also contains 150 mcg of additional active ingredients and 325 mcg of natural thymus extract.

The Benefits of TB4-Frag Oral and Frag Max

The Benefits of TB4-Frag Oral and Frag Max

TB4-Frag Oral and Frag Max can provide a number of benefits to the body, all of which drive its multiple use cases. While this peptide is most known for helping the body recover from injuries, it can also help calm muscles to avoid spasms, promote efficient nutrient exchange between blood cells, promote flexibility in the joints, and improve endurance and strength.

TB4 works to improve the production of T cells in the body, which works with the body’s immune system to combat diseases and allergens. While it boosts the immune system by ensuring healthy T cells, it also influences the B cells in the body to activate and develop plasma cells. TB4’s part in the body’s actin monomer-sequestering proteins ensures the body retains enough of the actin protein to ensure cells have structural support, can carry out biological processes, and can influence muscle movement and rebuilding.

TB4 can benefit the body

Here are some other ways TB4 can benefit the body:

Combating Arthritis Inflammation

Arthritis is a condition wherein the joints in the body experience inflammation and become stiff and painful. Arthritis is more common as we age but can also be caused by overuse, injury, immune reaction, and more. TB4 can help to reduce that inflammation and relieve the pain associated with arthritis.

Combating Arthritis Inflammation

Reducing the Risk of Blood Clots

As mentioned, TB4 helps to promote the healthy production of multiple types of blood cells. With healthy cells comes the healthy transfer of the oxygen and nutrients they carry, which keeps the body healthy overall. In addition, this can help to prevent excessive clotting after injury or surgery.

Helping Repair Soft Tissue Damage

Injuries regularly occur in the body’s soft tissues. There is the potential for accidental injuries, including cuts and scrapes. Intentional tissue injury caused by surgeries can also be considered tissue damage.

TB4 helps cells attract nutrients and other chemicals crucial for rebuilding. It also stimulates the formation of new blood vessels, reduces inflammatory cytokines (cell signalers), and can prevent excessive inflammation in the healing area. Together, these effects can help to speed healing and ensure the new tissue is healthy and functional.

Aid in Muscle Regeneration

TB4 Frag Oral and Max can help speed up the muscular recovery process. During exercise, especially strength training, muscle fibers are stretched, causing tiny tears within the muscle tissue. This process is normal and is the reason you feel sore the day after exercise. When the muscle fibers repair themselves, they become bulkier and stronger than they were before the exercise.

Aid in Muscle Regeneration

The rest period after exercise is when muscle repair happens, and can be aided by reduced activity, drinking water, and providing the body with good nutrition from a balanced diet. TB4 supplements can also be a crucial help. As with other types of soft tissue damage, supplementing the body with TB4 can help the body bounce back quicker and more effectively during the recovery process.

Ensures Immune Response

As the thymus, the producer of the TB4 peptide, is charged with maturing the body’s immune system, the fact that TB4 has immune capabilities should come as no surprise. Because of TB4’s influence on white blood cell growth, the body is able to better combat pathogen and allergen intruders by building natural antibodies that can prevent future occurrences. TB4 also helps to stimulate blood vessel formation, prevent inflammation, and improve cell function, which are all key to preventing disease.

Repair Cardiovascular and Neurological Damage

One of the many benefits associated with healthy blood cells is the ability to carry vital nutrients and oxygen throughout the body, improving tissue healing after damage. In particular, as a progenitor of blood vessel cells, TB4 can help the heart recover from damage after a heart attack. Similarly, this peptide’s ability to prevent cell death and promote nerve cell regeneration can positively influence neuronal plasticity – the brain and nervous system’s ability to recover from damage.

TB4-Frag Max and TB4-Frag Oral FAQs

While these two TB4 supplements are not identical, they do provide many of the same benefits. Here are the answers to some common questions about their effects.

How Does TB4-Frag Oral Work?
  • Promoting cell growth by sequestering actin. Actin is a protein responsible for building muscles and ensuring cell movement, growth, and healing occurs. TB4 is among a group of hormones that sequester, or retain, actin so the body can heal and grow.
  • Traveling directly to the source of injury or inflammation to provide necessary healing.
  • Attaching itself to the platelets that first arrive at the source of an injury. These cells begin the healing process.
  • Hinders the cells that are responsible for scar tissue at the source of the injury. An added benefit from this process is that scarring is often at a minimum or even nonexistent.
  • Hindering inflammatory cell activation reduces the inflammation at the injury so that healing can occur more quickly.
What Are the Side Effects of TB4-Frag Oral and Max?
While there are a number of benefits to TB4-Frag Oral and Max, there is also a minimal risk for TB4-Frag Max and TB4-Frag Oral side effects, as there are with any supplement. People with existing tumors, whether benign or cancerous, should seek medical advice before taking a TB4 product. Because of TB4’s influence on muscle growth and tissue stimulation, there is the potential for negative impacts on the tumor or cancer cells, making them difficult to treat.

Other side effects could include unexpected joint pain or redness, lethargy, decline in motivation, and headaches.

Is TB4-Frag Oral Considered a Steroid?
It is true that steroids act similarly to TB4-Frag in that they stimulate muscle growth and strength. However, they differ in their molecular structure and are, therefore, not the same. Steroids are made of fatty molecules, while peptides, such as TB4-Frag, are made of amino acid chains. Additionally, steroids typically produce a longer list of side effects than TB4-Frag.

Unfortunately, one similarity that peptides and steroids share is that they have been banned from use during competition in some athletic events. They have been classified as performance-enhancing supplements due to their healing and recovery capabilities. For this reason, TB4 supplements are banned by some professional sports’ governing bodies.

Can TB4-Frag Oral Work With Other Peptides?
TB4-Frag Oral can have multiple benefits on its own, but it can significantly help other peptides enact their effects on the body through peptide therapy. One of the most popular peptides to pair it with is BPC-157. One of the benefits of BPC-157 is that it helps repair neurological damage in order to prevent additional issues such as memory loss, motor functions, and coordination. With the addition of healthy cell growth from TB4-Frag, the neurological damage can not only gain the nutrients it needs from healthy cells but also help improve your overall mental wellness.
When Is the Best Time to Take TB4-Frag Oral or TB4-Frag Max?
Many supplements are best taken with food to prevent harmful side effects. However, TB4-Frag Oral and Max are best taken on an empty stomach – ideally, two hours after the last meal of the day or an hour before the first meal of the day. Foods could chemically interact with the supplement, minimizing its effectiveness. By taking the supplement on an empty stomach, you could maximize its beneficial properties.
Should Expecting Mothers or Children Take TB4-Frag Orally?
Although TB4 is produced naturally by the body at around age 15, it can be difficult to determine how a child’s body will react to the addition of peptides like TB4-Frag Oral. While TB4 can promote healthy growth in muscles and cells, the body of an individual under 18 is still developing. Therefore, it is unknown whether TB4 is safe and effective for children.

Research has been inconclusive for women who are pregnant or considering becoming pregnant. In one study, women experienced favorable prenatal outcomes when TB4 was incorporated into prenatal supplements. However, there could be negative impacts on other areas of the mother’s or growing baby’s body.

While you may have many more questions not answered here, these could provide you with some insight into TB4-Frag and how it could help you promote healing and recovery.

Where to Buy TB4-Frag Oral?

At Compounding Pharmacy of America, we pride ourselves in providing our customers with top quality health and wellness products. This includes compounded medications as well as supplements from our wellness shop. We can help you determine whether supplements like TB4-Frag Oral supplements should be a regular part of your peptide therapy.

In addition to TB4-Frag Oral, we offer TB4-Frag Max, which can provide up to 10 times the potency and benefits of TB4-Frag Oral. If you are in the process of determining which TB4 product would be best for you, consult with one of our highly trained team members, who can help guide you through their similarities and differences and match you with the right product or products for you. Our team of pharmacy professionals is available seven days a week to assist you with any questions you have about the benefits of TB4-Frag so you can make an informed decision.

TB4-Frag MAX

TB4-Frag Oral and TB4-Frag Max from the Wellness Shop

Whether you have experienced injury, surgery, or exercise, helping your body recover from stressors, strains, and stimulation is an important part of returning you to your normal routines and habits. In addition, building muscle can help boost your confidence and sense of accomplishment. You can improve your body’s response to each of these situations with TB4-Frag Oral and TB4-Frag Max.

At Compounding Pharmacy of America, our patients are our first priority. With our highly trained team ready to answer all of your questions, you will no doubt find the answers you need to feel confident in incorporating TB4 peptides into your life. Contact us today, and let us help you fuel your body so you can get back to your routine quickly.

Resources :

  1. Goldstein, A. L., Hannappel, E., Sosne, G., & Kleinman, H. K. (2011). Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opinion on Biological Therapy, 12(1), 37–51. https://doi.org/10.1517/14712598.2012.634793
  2. https://s3.amazonaws.com/aarm/conf/2020-annual/exhibitors/Thymosin%20Beta%204%20Frag%20Handout.pdf
  3. Thymosin Beta 4 |How TB4 Supports The Immune System. (2021, March 22). https://vitality-sciences.com/peptides/what-is-thymosin-beta-4/
  4. ‌Thymosin Beta 4 – A Healing Peptide | Regenerative Medicine Center – Dr. Valerie Donaldson MD Pittsburgh, Pennsylvania PA. (n.d.). Retrieved April 15, 2024, from https://regenerativemc.com/thymosin-beta-4/#:~:text=TB4%20has%20been%20shown%20to
  5. ‌Irobi, E., Aguda, A., Larsson, M., Christophe Guérin, Yin, H. L., Burtnick, L. D., Laurent Blanchoin, & Robinson, R. (2004). Structural basis of actin sequestration by thymosin-β4: implications for WH2 proteins. 23(18), 3599–3608. https://doi.org/10.1038/sj.emboj.7600372
  6. ‌Moon, E.-Y., Song, J.-H., & Yang, K.-H. (2007). Actin-Sequestering Protein, Thymosin-Beta-4 (TB4), Inhibits Caspase-3 Activation in Paclitaxel-Induced Tumor Cell Death. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 16(11), 507–516. https://doi.org/10.3727/096504007783438349
  7. ‌Sreenivas, S. (2021, March 25). What Are Peptides? WebMD. https://www.webmd.com/a-to-z-guides/what-are-peptides
  8. ‌Jakša Vukojević, Marija Milavić, Darko Perović, Spomenko Ilić, Andrea Zemba Čilić, Nataša Đuran, Sanja Štrbe, Zoran Zoričić, Igor Filipčić, Petrana Brečić, Sven Seiverth, & Predrag Sikirić. (2022). Pentadecapeptide BPC 157 and the central nervous system. Neural Regeneration Research, 17(3), 482–482. https://doi.org/10.4103/1673-5374.320969
  9. ‌Faa, G., Piras, M., Mancuso, L., Coni, P., Pichiri, G., Orrù, G., Fanni, D., Gerosa, C., Cao, G., Taibi, R., Pavone, P., & Castagnola, M. (2021). Thymosin beta-4 prenatal administration improves fetal development and halts side effects due to preterm delivery. European Review for Medical and Pharmacological Sciences, 25(1), 431–437. https://doi.org/10.26355/eurrev_202101_24411
  10. ‌Allison, L. (2022, April 29). What happens to your muscles during exercise and recovery? Longevity.Technology Lifestyle | Health, Fitness & Technology. https://longevity.technology/lifestyle/what-happens-to-your-muscles-during-exercise-and-recovery/

About Matt Poteet, Pharm.D.

Chief Operating Officer, The Compounding Pharmacy of America Matthew Poteet, Pharm.D. graduated with Honors from Lee University with a Bachelors of Science in Biological Science. After his undergraduate training, he completed the Doctor of Pharmacy program at Mercer University Southern School of Pharmacy, graduating in 2004. Dr. Poteet has spent much of his pharmacy career on staff at two of the most prestigious academic teaching hospitals in the Southeast; Emory University in Atlanta and Vanderbilt University Medical Center in Nashville. At these institutions he received extensive experience and training in sterile products compounding. He returned home to East Tennessee in 2010, where he has held the position of Pharmacy Director at two sterile products pharmacies in Knoxville. Matthew lives in Knoxville with his wife, Chris. Dr. Poteet is Tennessee’s first Board Certified Anti-Aging Pharmacist by the American Academy of Anti-Aging Medicine. Read More About Matthew Poteet, PharmD