One of Integrative Peptides’ most popular products, TB4-Frag, is now available as a new and improved peppermint-flavored oral spray. TB4-Frag Oral Spray harnesses the power of thymosin beta 4, also called TB4, a naturally occurring peptide found in the cells of humans and animals. Learn more about this essential peptide and the benefits it can have as a part of your supplement regimen.
What Is TB4?
Peptides are naturally occurring strands of amino acids produced by living things, including humans. The thymosin beta 4 active fragment is the active part of the thymosin beta 4 peptide produced naturally in your thymus gland.
The thymus is a small gland in the lymphatic system that creates and trains special white blood cells known as T-cells. These cells help your immune system fight disease and infection. Located in your upper chest behind your sternum, the thymus gland is most active during your childhood, and after puberty, the gland slowly starts to decrease in size and is replaced by fat.
Thymus-produced thymosin beta 4, or TB4, works by:
- Increasing actin, a protein that plays a critical role in cell motility, maintenance of cell shape and polarity, regulation of transcription, and muscle contraction.
- Traveling to injury sites to promote healing.
- Occurring in high concentrations in platelets, which are one of the first cells to arrive to repair a tissue injury.
- Decreasing scar tissue formation and fibrosis.
- Decreasing inflammation by preventing the activation of inflammatory cells.
While the human body produces TB4, supplementing that production with a TB4 product can help speed tissue repair and recovery, along with a host of other benefits.
How Does TB4-Frag Oral Spray Benefit Your Body?
There are many benefits to supplementing with TB4-Frag.
These include the following:
Supporting Healing and Recovery
The healing process after surgery, soft tissue injury, or even an intense workout can be slow, but TB4-Frag can help speed it up. The peptide supports tissue repair and wound healing and supports fibroblast growth to heal the body faster than usual. Reduced inflammation can lessen body aches and pain.
Repair Soft Tissue Damage
The body’s soft tissues are damaged regularly, either from accidental injuries like cuts or scrapes or intentional injuries during surgeries.
TB4-Frag aids in healing the body’s soft tissues through:
- Cell Migration and Proliferation – TB4-Frag promotes cell migration to the site of the injury, a critical step in the healing process. This allows cells responsible for repairing tissue to reach the damaged area and increases the number of cells at the injury site, which speeds up the process.
- Angiogenesis – Angiogenesis is the physiological process of forming new blood vessels from pre-existing vessels, and TB4 has been found to play a significant role in promoting this process. This can accelerate wound healing by supporting tissue repair and regeneration.
- Matrix Formation – The peptide may aid in the formation of the extracellular matrix, which is the structural support network that surrounds cells. A healthy matrix is essential for proper tissue function and strength.
Prevent Dead Tissue From Lack of Blood Supply
If blood is not adequately supplied to the various tissues throughout the body, they may die. This is a condition known as ischemia. TB4-Frag may work to increase blood vessel growth in tissues without proper blood flow, improve blood supply, reduce inflammation, and aid in cell survival by providing nutrients to these tissues.
Help Muscle Regeneration
As you exercise, muscle fibers are stretched, creating tiny tears. As the muscle fibers are repaired, they become stronger and bulkier. This is also why your muscles may be sore after strength training. TB4 Frag can help speed up the muscular recovery process and help you bounce back more quickly during your rest time. This occurs because the peptide can stimulate satellite cells, which are muscle stem cells located between the muscle fiber and its surrounding membrane. These cells grow and repair muscles.
Reduce Inflammation
TB4-Frag has been shown to have anti-inflammatory properties. After an injury, damaged tissue may become inflamed, causing pain and preventing recovery. TB4 facilitates the regulation of the assembly of G-actin monomers into filaments, which is important for muscle contraction and maintaining cell structure.
Additionally, due to these anti-inflammatory properties, TB4-Frag promotes wound healing and prevents the growth of fibroids, which are benign tumors in the uterus whose development is influenced by inflammation.
Improved Cell Health
TB4-Frag boosts cell health by protecting cells from hypoxia, oxidative stress, and inflammation and stimulates cell proliferation and migration. Additionally, TB4-Frag helps regulate actin filaments, which are important for cell shape, structure, and movement. Supported cell health also reduces the risk of excessive blood clots.
Improved Cardiovascular Function
TB4-Frag can improve heart function and support overall cardiovascular health by promoting cell survival, anti-inflammatory responses, and angiogenesis. The peptide can also prevent cell death and promote cell regeneration that promotes neuronal plasticity, supporting the heart’s ability to recover from damage.
Support Immune Response
Since TB4 influences white blood cell growth, TB4-Frag can support immune response and fight pathogens by building antibodies to prevent future illness. Additionally, it can help stimulate angiogenesis, prevent inflammation, and improve cell function, which are essential for effective immune response.
Improved Flexibility
TB4-Frag helps improve flexibility through increased cell elasticity, improved blood flow, enhanced tissue repair, and the promotion of collagen production. As you age, flexibility becomes even more important since flexible muscles recover more quickly.
Anti-Aging
TB-4 Frag may also aid in anti-aging due to lymphocyte maturation and differentiation – the proliferation of white blood cells. These processes are crucial for regulating immune responses, which usually slow down with age. This peptide helps rejuvenate at the cellular level and accelerate organ regeneration.
Other Benefits
Other benefits of taking TB4-Frag Oral Spray include improved joint health, support for your neurological health, accelerated hair growth, improved eye health, and improved liver health. In addition, TB4 is generally safer and harbors fewer side effects than steroids.
Conditions TB4-Frag Can Help Treat
TB4 has been widely recommended by medical professionals to support injury recovery and has been embraced by professional athletes to optimize their performance.
Additionally, TB4-Frag can be utilized to optimize care for these conditions:
- Arthritis – Since TB4-Frag combats inflammation, it can be effective in the reduction of joint pain and swelling associated with arthritis.
- Blood Clots – TB4-Frag improves cells in the body and can cause excessive blood clots. This helps to protect the heart against heart attacks and the brain against strokes, along with other traumatic brain injuries (TBI).
- Autoimmune Disease – Due to its benefits for the body’s immune system, TB4-Frag may be beneficial for reducing the effects of autoimmune diseases such as Lyme disease, systemic lupus erythematosus, multiple sclerosis, or traumatic brain injuries. It does this by addressing apoptosis in the cell lifecycle (natural cell death), finding senescent cells and modulating the immune response, promoting t-cell activity, restoring homeostasis, and regulating abnormal immune reactions seen in autoimmune disorders.
- Cardiovascular and Neurological Damage – TB4-Frag can help speed recovery from cardiovascular and neurological damage due to its ability to promote new blood cell creation.
Why An Oral Spray?
TB4-Frag Oral Spray contains over three times the amount of active peptide fragment per serving as the original TB4-Frag product. Oral sprays provide a more rapid absorption rate and a higher bioavailability than capsules because the peptide fragments are absorbed through the thin skin beneath the tongue. This skin is rich in tiny capillaries, meaning the supplement can quickly enter your bloodstream. By contrast, oral products that are swallowed must be digested and metabolized before they enter the bloodstream, a process that can take up to two hours.
In addition, pills and capsules usually must be taken at certain times of the day with food and water. Injections also require a scheduled appointment, which can be difficult if you’re busy. Oral sprays can be put in your pocket or purse; just spray two sprays twice per day in the morning and evening, and you’re good to go.
Finally, many people feel sprays are simply easier to use than capsules or injections. Some people have difficulties swallowing pills and capsules and dislike the pain of injections. Best of all, the peppermint taste can make you forget you’re taking a supplement, bringing more positivity to the experience.
TB4-Frag Oral Spray FAQs
The potential benefits of TB4-Frag are many, but it’s natural to want to learn more about how this supplement works. Here are some answers to the most common questions regarding this new spray.
Where To Buy TB4-Frag Oral Spray?
TB4-Frag Oral Spray is available on Compounding Pharmacy of America’s online wellness shop. Our pharmacists are available to answer any questions and determine whether supplements may benefit your health. Each team member is extensively trained, and we are committed to delivering personalized solutions for everyone.
Discover the Healing Power of TB4-Frag Oral Spray
At Compounding Pharmacy of America, we prioritize your unique needs and strive to provide professional compounding services as well as a diverse online wellness shop. As a result, we are accredited by the Pharmacy Compounding Accreditation Board (PCAB) and are LegitScript Certified. Our pharmacists are here to provide assistance and answer your questions about how you can introduce TB4-Frag Oral Spray into your health regimen. Contact us today to move toward a healthier you.
Sources:
- Goldstein, A. L., Hannappel, E., Sosne, G., & Kleinman, H. K. (2011). Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opinion on Biological Therapy, 12(1), 37–51. https://doi.org/10.1517/14712598.2012.634793
- Goldstein, A. L., Hannappel, E., Sosne, G., & Kleinman, H. K. (2011). Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opinion on Biological Therapy, 12(1), 37–51. https://doi.org/10.1517/14712598.2012.634793
- Kim, J., & De Jesus, O. (2023). Medication Routes of Administration. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK568677/
- Maar, K., Hetenyi, R., Maar, S., Faskerti, G., Hanna, D., Lippai, B., Takatsy, A., & Bock-Marquette, I. (2021). Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies. Cells, 10(6), 1343. https://doi.org/10.3390/cells10061343
- Adair, T. H., & Montani, J.-P. (2010). Overview of Angiogenesis. Nih.gov; Morgan & Claypool Life Sciences. https://www.ncbi.nlm.nih.gov/books/NBK53238/
- Gao, X.-Y., Hou, F., Zhang, Z.-P., Nuo, M.-T., Liang, H., Cang, M., Wang, Z.-G., Wang, X., Xu, T., Yan, L.-Y., Guo, X.-D., & Liu, D.-J. (2016). Role of thymosin beta 4 in hair growth. Molecular Genetics and Genomics: MGG, 291(4), 1639–1646. https://doi.org/10.1007/s00438-016-1207-y
- Ildiko Bock-Marquette, Maar, K., Maar, S., Balint Lippai, Gabor Faskerti, Ferenc Gallyas, Olson, E. N., & Srivastava, D. (2023). Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies. International Immunopharmacology, 116, 109741–109741. https://doi.org/10.1016/j.intimp.2023.109741
- Thapa, P., & Farber, D. L. (2019). The Role of the Thymus in the Immune Response. Thoracic Surgery Clinics, 29(2), 123–131. https://doi.org/10.1016/j.thorsurg.2018.12.001
Compounding Pharmacy of America is committed to delivering reliable, accurate, and actionable health information to empower you on your wellness journey. Our content is created and reviewed by a dedicated team of professionals, including experienced writers and licensed healthcare experts.
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